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Updated: Sep 9, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

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核タンパク質集積は,RNA処理を妨害し,OPMDの筋肉細胞モデルにおけるバイオメカニズムを変更する

Milad Shademan1, Sarah Flannery2, Erik Bos1

  • 1Leiden University Medical Centre, Leiden, Leiden, The Netherlands.

Aging and disease
|September 3, 2025
PubMed
まとめ

RNA結合タンパク質の集積は,眼筋ジストロフィー (OPMD) の筋肉細胞機能障害を引き起こす. この研究では,核のPABPN1がRNA代謝と細胞機能を損ない,OPMDとより広範な神経筋疾患の経路を結びつけていることが明らかになりました.

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Monitoring Protein Aggregation Kinetics In Vivo using Automated Inclusion Counting in Caenorhabditis elegans

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