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Updated: Sep 9, 2025

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity
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Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 7, 2019

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TGFβは,強いおよび中等なアゴニズム後にPTPN22経由による近接CD8+TCRシグナリングを制限する

Andrew J Gunderson1,2, Kelley Jordan1, Tomoko Yamazaki1

  • 1Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, OR, United States.

Journal of immunology (Baltimore, Md. : 1950)
|September 3, 2025
PubMed
まとめ

変形成長因子β (TGFβ) はT細胞受容体 (TCR) 信号伝達を抑制し,抗腫瘍免疫を阻害する. CD8+ T細胞のTGFβシグナル伝達を消去すると,細胞毒性が強化され,より効果的な抗腫瘍反応が促進されます.

キーワード:
PTPN22 についてTCRシグナリングTGFベータ区分する

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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses10:13

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