血清フェリチンと冠動脈疾患患者の全因死亡リスクとの関連

Zhi-Hui Jiang¹, Ming-Ming Lyu¹, Yu-Juan Feng¹

¹Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Clinics (Sao Paulo, Brazil)

|September 3, 2025

まとめ

高レベルのフェリチンは,冠動脈疾患 (CAD) の患者の全因死亡リスクの増加と関連しています. この発見は,フェリチンがこの集団における長期的な結果の潜在的予測因子であることを強調しています.

科学分野:

心血管医学
臨床生化学
流行病学

背景:

フェリチンは酸化した低密度脂質 (LDL) と関連しています.
高LDLは心血管疾患の危険因子として知られています.
血清フェリチンと冠動脈疾患 (CAD) の患者の長期的なアウトカムに関する研究は限られている.

研究の目的:

血清フェリチン濃度と長期の死亡率の関係を調べる
フェリチンがCADにおける有害な結果の独立した予測因子であるかどうかを判断する.

主な方法:

1089人のCAD患者の前向きなコホート研究 (2016年12月 - 2021年10月).
血清フェリチン基準で分類された患者: < 160 ng/ mL (n=715) と ≥ 160 ng/ mL (n=374).
主要エンドポイント: 60ヶ月以上の長期死亡率 (全因死亡率 - ACM,心臓死亡率 - CM).

主要な成果:

ACM (p=0. 002) とCM (p=0. 019) の発生率は,グループによって大きく異なる.
フェリチンは,コバリアート調整後のACMを独立に予測した (ハザード比 [HR]=2. 674, p=0. 016).
17件のACM,12件のCM,34件のMACCE,41件のMACEを記録した.

結論:

血清フェリチン濃度の上昇は,CAD患者の全因死亡リスクの増加と強く関連しています.
フェリチンはCADの管理において貴重な予後バイオマーカーとして機能する.

キーワード:

冠動脈疾患フェリチン死亡率予測する

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