薬物乱用のためのサイケデリック:女性が対象になっているか? スコーピングレビュー
Alexandra Wojdyslawski Nigri1, Ilana Falcão de Arruda2, Catarina Gouveia Ferreira Maia2
1School of Psychological Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
The International journal on drug policy
|September 3, 2025
まとめ
薬物使用障害 (SUD) のためのサイケデリックに関するほとんどの研究は,性やジェンダーの違いを調査していません. 将来の研究では,女性特有のSUD治療の有効性について これらの重要な要因を調査する必要があります.
科学分野:
- 神経科学
- 精神科
- 薬理学について
背景:
- 薬物使用障害 (SUD) は世界的な健康問題です.
- サイケデリック薬は SUD の新しい治療法として研究されています
- SUDの治療に対する女性の反応はしばしば異なっており,それにより個別のアプローチが必要となる.
研究 の 目的:
- サイケデリックに関する研究が 性別とジェンダーの違いをどのように扱っているかを検討する.
- SUDのサイケデリック療法における女性の特異性に関する研究のギャップを特定する.
主な方法:
- 4つの主要なデータベース (Embase,PubMed,BVS,PsyNet) で包括的な文献検索が行われました.
- 薬物乱用に関するサイケデリックを調査した研究も含まれていた.
- 観察的研究と実験的研究の両方を検討し,追加の関連する研究のために参照リストをスクリーニングしました.
主要な成果:
- 75件のうち46件は女性の割合が不足し,9件は女性を含まなかった.
- 性別を考慮した研究はわずか13件で,性別別の結果は5件報告された.
- 性別に基づく結果を分析した研究も少なく,性差を認めた研究も少なく,性/ジェンダーを結論に含めたものはなかった.
結論:
- SUDのサイケデリックに関するほとんどの研究は,性やジェンダーの影響を調査していません.
- 性別や性別がSUDのサイケデリック治療に対する反応にどのように影響を与えるかを調査する研究を奨励する重要な必要性があります.
関連する概念動画
Hallucinogens and Psychedelics
282
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
282
CNS Stimulants: Psychedelic Agents
241
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
241
Altered States of Awareness
457
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
457
An Overview of Psychoactive Drugs
294
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
294
Substance Use Disorders Affecting Sleep
216
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
216
Drug Abuse and Addiction: Pharmacological Phenomena
655
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
655


