肌の表面でのストレスをベースとするバイオマーカーは,筋筋関節の痛みに関連した軟組織の移動における非対称性を区別する
Anika R Kao1, Terry M Loghmani2, Gregory J Gerling1
1Mechanical and Aerospace Engineering, School of Engineering and Applied Science, University of Virginia, Charlottesville, VA, USA; Systems and Information Engineering, School of Engineering and Applied Science, University of Virginia, Charlottesville, VA, USA.
Journal of the mechanical behavior of biomedical materials
|September 3, 2025
まとめ
この研究では,慢性筋骨格痛の重要な要因である 筋筋組織の動きを客観的に測定するための光学バイオマーカーを導入します. 結果は,自己報告された痛みと相関する個々の組織の変化を明らかにし,臨床評価を助けます.
科学分野:
- バイオメカニカルエンジニアリング
- 医療用イメージング
- 筋骨格研究
背景:
- ミオファシアル組織の評価は,現在主観的な臨床評価に基づいています.
- 改善された診断と治療のために,筋筋組織の移動性を客観的に定量化することが必要です.
研究 の 目的:
- 筋筋組織の移動性を定量化するための光学バイオマーカーを開発し,検証する.
- 組織移動の客観的な測定値と自己報告の痛みとの関係を調査する.
主な方法:
- 3つの高解像度のカメラで 皮膚表面の変形を追跡しました
- 準永久性タトゥーを参加者に施して 胸頸部部を正確に追跡した
- 上部と下部の方向に伸びた組織から 11のストレートベースの光学バイオマーカーを導いた.
主要な成果:
- 集約されたデータは明確な方向性 (上位と下位) を示したが,双方向性ではなかった.
- 9/ 19の参加者において,個別分析により,組織の移動性における重要な双方の不対称性が明らかになった.
- 8/9の参加者の双方の移動能力の差異は,自己報告の痛みの差異と相関していた.
結論:
- 皮膚表面の光学追跡は,筋筋組織の硬さのための客観的なバイオマーカーを提供します.
- 組織の移動における個々の双方の非対称性は,痛みの報告と一致する.
- 骨髄組織の客観的な評価は,慢性的な筋骨格の痛みの管理に不可欠です.
さらに関連する動画
07:07Biomechanical Characterization of Human Soft Tissues Using Indentation and Tensile Testing
Published on: December 13, 2016
32.1K
06:28Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
Published on: December 13, 2024
648
関連する概念動画
01:16Sensory Functions of the Skin
9.1K
The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
9.1K
01:11Introduction to Connective Tissues
19.1K
Connective tissues are one of the four main tissue types in humans that are extensively present in the body. They are characterized by cells embedded in an extracellular matrix (ECM) composed of a ground substance and three main types of protein fibers— collagen, elastic, and reticular fibers. The ground substance of connective tissues can range from a watery and jelly-like consistency to mineralized and hard. The wide variety of cells in the connective tissues include fibroblasts,...
19.1K
01:13Dense Connective Tissue
10.9K
Dense connective tissue contains more collagen fibers than loose connective tissue. As a consequence, it displays greater resistance to stretching. There are two major categories of dense connective tissue— regular and irregular.
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
Dense Regular Connective Tissue
In dense regular connective tissue, fibers are arranged parallel to each other, enhancing its tensile strength and resistance to stretching in the direction of the fiber orientations. Ligaments and tendons are made of dense regular...
10.9K
01:21Layers of Connective Tissue Proper
8.0K
Fascia, a thin layer of fibrous connective tissue, is distributed throughout the body. It demarcates and forms a supportive covering over skeletal muscles, bones, blood vessels, and organs. There are three main types of facia— superficial fascia, deep fascia, and subserous fascia. These are all present at different depths in the body. Fascia reduces the friction and permits muscles, joints, and organs to easily slide against each other, facilitating movement of the body and preventing...
8.0K
01:11Papillary Dermis
5.8K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.8K
01:26Bone Markings
8.8K
Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
8.8K