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Updated: Sep 9, 2025

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
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Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Published on: October 20, 2022

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ZBP1-RIPK1軸によるZ-核酸の先天的な免疫感知は,アルツハイマー病における神経炎症を誘発する

Ziwen Song1, Xingxing Xie2, Yulu Chen2

  • 1Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 101408, China.

Immunity
|September 3, 2025
PubMed
まとめ

Z-DNA結合タンパク質1 (ZBP1) は,アルツハイマー病 (AD) のマイクログリアで酸化したミトコンドリアDNAを感知し,神経炎症を引き起こす. ZBP1-RIPK1経路をターゲットにすることで,ADの新たな治療戦略を提供することができる.

キーワード:
8-オキシグアニンアルツハイマー病DNAの断片化RIPK1 についてZDNA についてZBP1 についてアミロイドβミトコンドリアDNA神経炎症酸化ストレス

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