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Updated: Sep 9, 2025

In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein
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ポリセリン媒介によるFAF2/UBXD8のターゲティングは,tauの集積を改善する

Meaghan Van Alstyne1, Georgia Brown2, Vanessa L Nguyen3

  • 1Department of Biochemistry, University of Colorado, Boulder, CO, USA; Howard Hughes Medical Institute, University of Colorado, Boulder, CO, USA.

Neuron
|September 3, 2025
PubMed
まとめ

研究者は,FAF2/UBXD8のようなタンパク質を標的とするポリセリン領域を用いた新しい戦略を特定し,毒性タウの蓄積を制限しました. このアプローチは 神経変性疾患の動物モデルにおいて有望であることが示されています

キーワード:
FAF2 についてUBXD8 について神経変性ポリセリンタンパク質の集積タウタオパシー

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