ヒトサン基の二重放出コアシェルのマイクロニードルパッチで,ヒドロフィールおよびヒドロホーブ薬の連続的な経皮投与:インビトロアプローチ
Fatemeh Babapour1, Fariba Ganji1, Zahra Faraji Rad2
1Biomedical Engineering Group, Faculty of Chemical Engineering, Tarbiat Modares University, Tehran 14115-143, Iran.
International journal of biological macromolecules
|September 3, 2025
まとめ
この研究は,新型のコア/シェルマイクロニードル (MN) パッチを二相薬剤投与のために提示しています. 革新的な設計により,単一の投与で迅速かつ持続的な治療効果が得られ,従来のMNの限界を克服できます.
科学分野:
- バイオマテリアル科学
- 薬物投与システム
- ナノテクノロジー
背景:
- 従来のマイクロニードル (MNs) は,製造の複雑さと機械的な頑丈さで課題に直面しています.
- 効果的な薬剤投与には,異なる治療需要に合わせた放出プロファイルが必要です.
研究 の 目的:
- 連続薬剤の放出のための二重機能のコア/シェルMNパッチを開発し,特徴づけること.
- 新しいMNプラットフォームの製造,機械的特性,皮膚の浸透,および薬物の放出運動を評価する.
主な方法:
- 統合3Dプリントと鋳造技術を使用して,コア/シェルMNの製造.
- コンフォカルとスキャニング電子顕微鏡による形態学的分析.
- 機械的強度,皮膚挿入,および組織学的評価
- フランツ拡散細胞を用いたex vivo薬剤放出試験で,水性および水害性のモデル薬剤を使用した.
主要な成果:
- 皮膚に浸透するのに十分な機械的強度を持つ,明確に定義されたコア/シェルのMNの製造を成功させた.
- シェル層から水性ロダミンBの迅速な放出 (~99%) は180分以内です.
- 核層から24時間以上持続的な水害性メチレンブルーの放出 (~92%)
結論:
- 開発されたコア/シェルMNプラットフォームは,順次および二段階の薬物放出を効果的に達成します.
- この新しいアプローチは 医学的な応用において 治療を制御する有望な戦略です
- 統合された製造方法は,従来のMN生産に有効な代替手段を提供します.
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