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Updated: Sep 9, 2025

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

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Cas9はCRISPR RNAの豊富さを感知し,CRISPRスペーサーの獲得を調節する

Xufei Zhou1, Rucheng Diao2, Xin Li1

  • 1Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.

Nature
|September 3, 2025
PubMed
まとめ

Neisseria apoCas9は,その RNA パートナーなしで,CRISPRの免疫記憶の獲得を強化します. このタンパク質はセンサーとして機能し,新しい免疫記憶の形成を促し,スペーサーの獲得を調節することで自己免疫を予防します.

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