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Updated: Sep 9, 2025

Aip1p Dynamics Are Altered by the R256H Mutation in Actin
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APE1活性部位残留物 Asn174はAP部位を安定させ,触媒作用に不可欠である

Kaitlin M DeHart1, Nicole M Hoitsma2, Spencer H Thompson1

  • 1Department of Biochemistry and Molecular Biology, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA.

The Journal of biological chemistry
|September 3, 2025
PubMed
まとめ

Apurinic/Apyrimidinic endonuclease 1 (APE1) の残基であるN174はDNA修復に不可欠である. N174の変異はAP部位の分裂を阻害し,DNAの安定化と最適の活性部位環境の維持におけるその役割を強調する.

キーワード:
ベース・エクシション・リペア (BER)DNA エンドヌクレアゼDNA 修復酵素触媒酵素構造

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