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Updated: May 27, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

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NEUROD1,ASCL1,POU2F3 と YAP1 の表現シグネチャーの包括的な分析は,潜在的治療的意味を持つユニークなLCNECサブグループを明らかにします

Frank W J Heijboer1, Jules L Derks1, Dana A M Mustafa2

  • 1Department of Respiratory Medicine, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

Laboratory investigation; a journal of technical methods and pathology
|September 3, 2025
PubMed
まとめ

大細胞神経内分泌がん (LCNEC) は,NEUROD1,ASCL1,POU2F3,およびYAP1 (NAPY) 発現に基づいて5つのサブタイプに分類することができます. これらのサブタイプは,控えめな差別を提供し,LCNECの将来のパーソナライズされた治療戦略を導くことができます.

キーワード:
ASCL1 について大細胞神経内分泌がんNEUROD1 についてPOU2F3 についてYAP1 について免疫ヒストケミストリー標的型療法

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Enumeration of Neural Stem Cells Using Clonal Assays

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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

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Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...