COVID-19肺炎で入院した患者の肺経泡通過
Hooman Poor1, Adeel Abassi2, Daniel Howell3
1Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA hooman.poor@mountsinai.org.
BMJ open respiratory research
|September 3, 2025
まとめ
肺を通過するバブルトランジット (TPBT) は,COVID-19肺炎患者の間で一般的であり,時間とともに増加します. TPBTと心拍数上昇は 病院での死亡リスクの増加と関連しています
科学分野:
- 心臓病科
- 肺科
- 神経学
背景:
- COVID-19肺炎におけるトランスプルモナリーバブルトランジット (TPBT) の流行については,さらなる調査が必要である.
- 過去の研究では,トランスクレニアル・ドップラー (TCD) を用いたTPBTの発生率が高いことが示された.
研究 の 目的:
- 住院中のCOVID-19肺炎患者のTPBTの有病率を確認し,さらに調査する.
- TPBT,心拍数,入院死亡率との関連を評価する.
主な方法:
- 呼吸器支援を必要とするCOVID-19肺炎の入院患者91人が登録されました.
- トランスクラニアル・ドップラー (TCD) 研究は,入学時に実施され,約7日および14日後に実施された.
- 参加者は,鼻カヌーラ,高流量鼻カヌーラ,非侵襲的換気,機械的な換気,およびECMOを含む様々な呼吸支援を受けた.
主要な成果:
- 参加者の36%が TPBT を最初のTCDで示した.
- TPBTの流行率は,第2の評価では55%,第3の評価では85%に増加した.
- TPBTと心拍数上昇は,入院死亡の増加と関連していました (p=0. 02).
結論:
- 住院中のCOVID-19肺炎患者のTPBTの罹患率は,以前に報告されたより高い.
- TPBTの罹患率は 病院に入院した患者の生存期間とともに増加しています
- TPBT患者の心拍数上昇は死亡率の重要な予測因子です.
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