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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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男性の性別,糖尿病,およびワクチン接種されていない状態が,リウマティック疾患の患者における2019年コロナウイルス病の悪化要因である:オミクロン変異期間の日本の北関東地域の単一センター分析

Fuminori Taniguchi1, Hironobu Komine1, Kohei Morikawa1

  • 1Division of Rheumatology and Clinical Immunology, Department of Medicine, Jichi Medical University, Japan.

Internal medicine (Tokyo, Japan)
|September 3, 2025
PubMed
まとめ
この要約は機械生成です。

リウマチ病患者のCOVID-19のアウトカムは,オミクロン変種期間中に一般的に好意的であった. 男性の性別,予防接種の欠如,糖尿病は2019年の重症コロナウイルス病の危険因子として特定されました.

キーワード:
コロナウイルスオミクロン変種糖尿病 糖尿病多変数ロジスティック回帰分析リウマティック疾患ワクチン接種

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科学分野:

  • リウマトロジ
  • 感染症
  • 公衆衛生

背景:

  • リウマティック疾患の患者は,COVID-19のような感染症による重篤な結果のリスクが高くなります.
  • オミクロン変種は,免疫力が低下した集団におけるCOVID-19の管理にユニークな課題をもたらした.

研究 の 目的:

  • 2019年コロナウイルス病 (COVID-19) の悪化に関連したリスク要因をレウマティック疾患の患者で特定する.
  • オミクロン変異の急増期におけるリウマチ病患者のCOVID-19アウトカムを分析する.

主な方法:

  • 2022年1月から2023年12月までの間にCOVID-19と診断されたリウマティック疾患の78人の患者を対象に遡及的研究が行われました.
  • 収集されたデータには,人口統計,リウマティック疾患の詳細,ワクチン接種状況,併発症,COVID-19の重症度,およびアウトカムが含まれています.
  • 多変量ロジスティック回帰分析は,中度から重度のCOVID-19の重要なリスク要因を決定するために使用されました.

主要な成果:

  • ほとんどの患者 (78.2%) は軽度のCOVID-19を患ったが,21.8%は中度から重症だった.
  • 中度から重度のCOVID-19のリスク要因には,男性 (p=0.012),未接種者 (p=0.031) および糖尿病 (p=0.018) が含まれていた.
  • 多変量分析では,特定の血液検査結果が重度の有意な予測因子とは認められなかった.

結論:

  • リウマティック疾患とCOVID-19の患者の大半は,オミクロン変種期間中に好ましい結果を出しました.
  • 併発性疾患,特に糖尿病の効果的な管理とワクチン接種の促進は,この集団における重度のCOVID-19の予防に不可欠です.