関連する実験動画

Updated: Sep 9, 2025

A Model of Reverse Vascular Remodeling in Pulmonary Hypertension Due to Left Heart Disease by Aortic Debanding in Rats
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Published on: March 1, 2022

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肺動脈高血圧における血管改造に関与する成長因子

Aya Yamamura1

  • 1Department of Physiology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan.

Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi
|September 3, 2025
PubMed
まとめ

血小板由来成長因子 (PDGF) は,肺動脈の滑らかな筋肉細胞の増殖を促進することによって,肺動脈高血圧 (PAH) を誘発する. イマチニブまたはコロソリック酸でPDGFシグナル伝達を抑制すると,ネズミの細胞成長が低下し,血管再構成が改善された.

キーワード:
成長因子拡散肺高血圧滑らかな筋肉血管の改造

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