不眠症のがん生存者における昼夜リズム障害を検出するための新しいマーカーとして,血液クロック相関距離 (Blood Clock Correlation Distance, Blood CCD)
Brian J Altman1,2, Po-Ju Lin3,4, Lindsey J Mattick4
1Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY, USA. Brian_Altman@URMC.rochester.edu.
BJC reports
|September 3, 2025
まとめ
無眠症の癌の生存者は 昼夜リズムが乱れていて 血液CCDで測定できます この新しいバイオマーカーは 不眠症の重さと相関しており 癌に関連した睡眠障害の 診断に役立つ可能性があります
科学分野:
- 腫瘍学
- 睡眠医学
- クロノバイオロジー
背景:
- 不眠症は 癌の生存者にとって 常見で 衰弱する副作用で 客観的な生化学的マーカーが欠けています
- 睡眠などの生理学的プロセスを 制御する24時間のサイクルである 昼夜リズムが乱れると 不眠症に繋がります
- YOCAS-II試験では,生存者におけるヨガと認知行動療法 (CBT-I) を調査した.
研究 の 目的:
- 睡眠障害を患った癌の生存者における 昼夜リズム障害の評価を 新しい血液ベースの方法によって行う
- この集団における睡眠不全の重症度との相関性があるかどうかを判断する.
主な方法:
- 血液のRNA配列を介して生体リズムを生物化学的に評価するために,新しい方法であるBloodCCDが使用されました.
- 血液CCDはクロック相関距離 (CCD) から派生し,血液中の42の毎日の振動遺伝子の発現を分析します.
- YOCAS- II試験に参加した不眠症の癌生存者からデータ収集されました.
主要な成果:
- 癌の生存者は,健康な個人と比較して,非常に高いBloodCCDスコアを示し,生理時計の障害を示した.
- 不眠症の重度とBloodCCDのスコアが悪くなったとの間に有意な相関が観察されました.
- YOCASヨガと行動プラセボグループの両方の参加者は,BloodCCDと不眠症の間の相関を示しました.
結論:
- 血液CCDは,がんの生存者における昼夜リズム障害を検出するための信頼できるバイオマーカーとして潜在性を示しています.
- この患者群における不眠症の重度の客観的な指標として機能する.
- この発見は 癌の治療後の睡眠障害に対する 標的型介入の道を開きます
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