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Updated: Sep 9, 2025

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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ワクチンと免疫療法薬のための新しい戦略としてMHC-Eをターゲットにする

Klaus Früh1, Persephone Borrow2, Geraldine M Gillespie2

  • 1Vaccine & Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR, USA. fruehk@ohsu.edu.

Nature reviews. Immunology
|September 3, 2025
PubMed
まとめ

メジャー・ヒストコンパティビリティ・コンプレックスE級 (MHC-E) タンパク質は,自然殺人細胞 (NK細胞) やT細胞のような免疫細胞を調節する. MHC-Eの相互作用をターゲットにすることで,新しいがんや感染症の免疫療法やワクチンの可能性が生まれます.

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