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アマゾンの魚,コロソマ・マクロポムム (Colossoma macropomum) で,殺虫剤フィプロニルによって引き起こされる神経毒性作用とオスモレギュレーションの不均衡
Ducilene do Carmo da Silva1, Gilzelle Maria da Luz Silva2, Liana Bezerra Dias de Lima2
1Laboratory of Comparative Animal Morphophysiology, Center of Integrated Sciences, Federal University of Northern Tocantins, Avenida Paraguai s/n°, Araguaína, TO, 77824-838, Brazil.
Environmental science and pollution research international
|September 3, 2025
まとめ
魚の急性フィプロニル曝露は神経毒性であり,筋肉アセチルコリネステラーゼ (AChE) に影響し,神経筋機能を損なう. オスモレギュレーションを妨害し,イオンバランスと長期生存の可能性に影響します.
科学分野:
- 環境毒理学
- 水中の生態学
- 魚の生理学
背景:
- 広く使用されている殺虫剤であるフィプロニルは 水中の生態系を汚染しています
- 虫殺剤の存在は魚の健康と発達に リスクをもたらします
- 魚に対するフィプロニルの神経毒性およびオスモレギュレータ作用は調査が必要である.
研究 の 目的:
- フィプロニルが魚に与える神経毒性について調べる
- フィプロニル曝露による光調節効果を評価する.
- 魚の脳との酵素活性,組織病理,形態生理の変化を分析する.
主な方法:
- Colossoma macropomumをフィプロニル (40μg L−1と160μg L−1) に96時間さらした.
- 血,白肌,脳,の組織を分析する.
- 酵素活性アッセイ (アセチルコリネステラゼ),組織病理学,およびオスモイオン調節分析.
主要な成果:
- F160群の筋肉アセチルコレネステラス (AChE) 活性が増加し,神経筋肉の交差点における神経毒性を示す.
- 脳組織病理学では 細胞内腫が確認されました AChEが常に活動しているにもかかわらずです
- プラズマのオスモイオン調節の不均衡が観察され,Na+とK+の濃度が変化し,オスモラリティが増加した.
結論:
- フィプロニルの曝露は神経毒的効果を誘発し,魚の神経筋伝播を阻害する.
- フィプロニルは魚のオスモイオン調節を妨害し,の生理学的プロセスに影響を与えます.
- これらの生理学的障害は水中の魚の生存を脅かしている.
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