Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Aging01:26

Aging

179
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
179
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.4K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

An encyclopedia of human enhancer-gene regulatory interactions.

Nature·2026
Same author

A linguistics-based algorithm for RBP motif and context discovery.

bioRxiv : the preprint server for biology·2026
Same author

Transcription factor NFYA directs male meiotic entry by regulating accessible chromatin at meiotic promoters in mice.

The EMBO journal·2026
Same author

Inflammation rewires the enteric nervous system through neurogenic monocyte recruitment.

The Journal of experimental medicine·2026
Same author

Transposable element-gene chimera cartography, origination and role in enhancing transcriptome plasticity.

Nature structural & molecular biology·2026
Same author

A novel NLP-based method and algorithm to discover RNA-binding protein (RBP) motifs, contexts, binding preferences, and interactions.

RNA (New York, N.Y.)·2026

関連する実験動画

Updated: Sep 9, 2025

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

3.1K

老化する人間の脳における単細胞のトランスクリプトミックの変化とゲノムの変化

Ailsa M Jeffries1, Tianxiong Yu2, Jennifer S Ziegenfuss1

  • 1Department of Molecular, Cell and Cancer Biology, Genome Integrity Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.

Nature
|September 3, 2025
PubMed
まとめ

細胞の損傷は老化を促します この研究では ヒトの前頭皮質の遺伝子発現と ゲノム変化が 生涯を通じて明らかになり 脳細胞の発達と老化ダイナミクスを強調しています

さらに関連する動画

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

976
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.5K

関連する実験動画

Last Updated: Sep 9, 2025

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche
08:16

Fluorescence-Activated Nuclei Negative Sorting of Neurons Combined with Single Nuclei RNA Sequencing to Study the Hippocampal Neurogenic Niche

Published on: October 20, 2022

3.1K
Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
04:22

Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

Published on: May 20, 2024

976
Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
12:28

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

17.5K

科学分野:

  • 神経科学
  • ゲノミクス
  • 分子生物学

背景:

  • 細胞の損傷は年齢とともに蓄積され 老化プロセスに寄与します
  • 人間の前頭前皮質の年齢関連の変化は 認知機能に影響を及ぼします

研究 の 目的:

  • ヒトの前頭皮質の遺伝子発現と ゲノム変異を 生涯で特定する
  • ヒトの脳の発達と老化のトランスクリプトミックとゲノム学的な動態を理解する

主な方法:

  • 単核RNAシーケンシング (snRNA-seq)
  • 単細胞全ゲノムシーケンシング (scWGS)
  • 空間トランスクリプトミクス

主要な成果:

  • 神経発達遺伝子発現の 幼児特有の細胞群を特定した.
  • 細胞型における恒常性遺伝子の年齢関連ダウンレギュレーションを観察した.
  • ニューロン特異的な遺伝子の 安定した発現を 生涯で見つけました
  • 遺伝子転写と抑制と相関する 2つの年齢に関連した変異のサインを検出しました
  • ニューロンの遺伝子長さと発現に依存する体内の変異率を明らかにした.

結論:

  • 人間の脳の発達と老化について 洞察力を与えてくれます
  • ヒトの生涯におけるトランスクリプトミックとゲノムの変化を明らかにする.
  • 遺伝子の変異を 老化した脳の 転写図と関連付けています