関連する実験動画

Updated: Sep 9, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
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Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

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老化因子EPS8は,RACシグナリング過活性化により,疾患に関連するタンパク質の結合を誘発する

Seda Koyuncu1,2, Yaiza Dominguez-Canterla3,4, Rafael Alis3,4

  • 1Institute for Integrated Stress Response Signaling, Faculty of Medicine, University Hospital Cologne, Cologne, Germany. skoyunc2@uni-koeln.de.

Nature aging
|September 3, 2025
PubMed
まとめ

老化により神経変性疾患が加速し,EPS8/RACシグナル伝達が活性化し,タンパク質の蓄積が促進されます. この経路とUSP4を阻害すると,結合と神経変性が減少し,年齢関連の疾患の治療目標となる可能性があります.

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