ボスウェル酸とカーノシン・アメリアートは,Nrf2/HO-1とPI3K/AKT経路を調節するバナジル硫酸誘発性腎臓損傷
Ghada M Gad1, Nahla S Kotb2, Khalid S Hashem3
1Biotechnology and Life Sciences Department, Faculty of Postgraduate Studies For Advanced Sciences, Beni Suef University, Beni-Suef, 26511, Egypt.
Biological trace element research
|September 3, 2025
まとめ
ボスウェル酸とカルノ酸は,酸化バランスを回復し,線維症を軽減することにより,ヴァナジル硫酸による腎臓損傷から保護します. これらの天然化合物は,化学療法による腎中毒を軽減するための潜在的な治療戦略を提供します.
科学分野:
- 薬理学について
- 毒理学について
- 腎臓科
背景:
- 腎中毒性は,特定の化学療法薬の重要な懸念事項である.
- バナジル硫酸塩 (VOS) は腎臓毒性物質で,酸化ストレスと腎臓損傷を引き起こすことが知られている.
- VOS誘発性腎毒性に対する保護剤の特定は,患者の安全性にとって極めて重要です.
研究 の 目的:
- ボスウェル酸 (BA) とカルノ酸 (CA) のVOS誘発性腎臓毒性に対する保護効果をラットモデルで調査する.
- 酸化ストレスと重要なシグナル伝達経路を伴う根本的なメカニズムを解明する.
主な方法:
- 男性のウイスター・アルビノラットは,対照群,VOS,BA,CA,BA+VOS,CA+VOSの6つのグループに分けられました.
- 動物にはVOS (50 mg/ kg,i. p) を投与した. 毎週) と/またはBAまたはCA (100 mg/kg,毎日口服) を6週間投与する.
- 腎機能マーカー (クレアチニン,血中尿素),酸化ストレスパラメータ (MDA,SOD,GSH,GR,CAT),遺伝子発現 (iNOS,PI3K,AKT,Nrf2,HO-1) を分析した.
主要な成果:
- 腎臓機能不全を示唆するVOS投与は,クレアチニンと血尿素を有意に増加させた.
- VOS誘発の酸化ストレスには,MDAの増加とSOD,GSH,GR,CATの活動低下が示された.
- BAとCA治療は,VOS誘発性腎臓毒性を有意に改善し,酸化バランスを回復し,腎臓のMDAレベルを低下させた.
- VOSはINOS,PI3K,AKT,Nrf2,HO-1の腎臓のmRNA発現を調節し,BAとCA治療はこれらの発現を正常化しました.
- VOSで治療されたラットの線維症は,BAまたはCA投与後に減少した.
結論:
- ボスウェル酸とカルノ酸は,バナジル硫酸による腎臓損傷に対する重要な腎臓保護効果を示しています.
- これらの保護効果は,抗酸化防御システムの回復とPI3K/AktとNrf2/Ho-1の信号伝達経路の調節によって媒介されます.
- BAとCAは化学療法による腎臓毒性の管理に 有望な天然化合物です
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