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Updated: Sep 9, 2025

Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro
13:20

Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-induced HN4 Cell Apoptosis In Vitro

Published on: July 17, 2018

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ミトコンドリア・レドックス・ホメオスタシスの破壊によるミトコンドリア・プロテアゼCLPPとLONP1を標的にすることで,タンパク質毒性ストレスが誘発され,腫瘍の進行が抑制される

Shivani R Nandha1,2, R S Patwardhan1,2, Deepak Sharma1,2

  • 1Radiation Biology & Health Sciences Division, Bio-science Group, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India.

Cell communication and signaling : CCS
|September 3, 2025
PubMed
まとめ

ミトコンドリアの反応性酸素種 (mtROS) を誘導する薬剤でがん細胞ミトコンドリアを標的とすることは,タンパク質毒性ストレスと細胞死を引き起こす可能性があります. このアプローチは,トリプルネガティブ乳がん (TNBC) のような攻撃的ながんの治療に有望である.

キーワード:
ミトコンドリアミトコンドリアタンパク質酸化ストレスタンパク質毒性ストレス解き放たれたタンパク質反応

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