システム性免疫炎症指数と中性粒子のリンパ球比: 膀過活性のU型関連

Qinglong Yang¹, Haolin Chen², Hanyuan Lin^1,3

¹Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.

Lower urinary tract symptoms

|September 3, 2025

まとめ

システム免疫炎症指数 (SII) と中性細胞対リンパ球比 (NLR) は,膀過活動 (OAB) のリスクを示す可能性があります. SIIとNLRのレベルがOABの有病率増加と関連している.

科学分野:

泌尿器科
免疫学
公衆衛生

背景:

膀活動過多 (OAB) は,生活の質に影響を与える一般的な状態です.
炎症と免疫反応は様々な慢性疾患でますます認識されています.

研究の目的:

組織性免疫炎症指数 (SII) と中性細胞対リンパ球比 (NLR) と過活性の膀 (OAB) の罹患率との関連を調査する.

主な方法:

NHANESデータ (2005年−2018年) を用いた米国成人22,343人 (≥20歳) の横断研究.
多変量ロジスティック回帰と制限キュービックスライン (RCS) 分析を使用した.
結論を検証するために,サブグループと感受性分析が行われました.

主要な成果:

RCSの分析では,SIIとNLRとOABの両方のU型関係が明らかになりました.
増加したSII (> 6. 13) とNLR (> 0. 65) はOABの罹患率と正に関連していた (ORはそれぞれ1. 32と1. 40).
下のSII (≤6. 13) は,OAB (OR 0. 83) とのマイナスの関連を示した.

結論:

SIIとNLRは,過活動性膀リスクの予測バイオマーカーとして潜在的であることを示しています.
これらの炎症マーカーは,OABのリスクが高い個人を特定するのに役立ちます.

キーワード:

NHANES について NLR について SII について中性粒子膀の過剰活動

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