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Updated: Sep 9, 2025

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules
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癌細胞から分泌されるmiR-33aは,ストロマにおけるポリアミン代謝を標的とし,腫瘍形成を促進することによって,ストレス粒子の形成を減少させる

Sheng Hu1, Xu Li1, Qixin Hu2

  • 1State Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Research Center for Basic Biological Sciences, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, RNA Institute, Wuhan University, Wuhan, China.

Journal of extracellular vesicles
|September 4, 2025
PubMed
まとめ

栄養ストレス下にあるがん細胞は,外細胞膀 (EVs) を介してmiR- 33aを分泌し,腫瘍の生存を促進するために,がんに関連した線維芽細胞を標的にします. この過程には鉄の濃度,ポリアミン代謝,および表遺伝的調節が含まれます.

キーワード:
エピジェネティック・リプログラミング細胞外膀ポリアミンの代謝ストレス・グランブル腫瘍の微小環境

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