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Updated: Sep 9, 2025

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
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C57BL/6およびBALB/cマウスの亜株のフェノタイプおよび遺伝的差異に関する簡潔な紹介

Lan Zhao1,2, Jie Wei1,2, Bingfei Yue1,2

  • 1Division of Laboratory Animal Monitoring, National Institutes for Food and Drug Control, Beijing, China.

Animal models and experimental medicine
|September 4, 2025
PubMed
まとめ

C57BL/6やBALB/cのようなマウスサブストレインを理解することは,信頼性の高い生物医学研究にとって極めて重要です. このレビューは,最適な実験選択を助けるために,それらの遺伝的および現象的違いを詳細に説明します.

キーワード:
BALB/c マウスC57BL/6 マウス遺伝的差異フェノタイプの違いサブストレイン

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Background and Environment Affect Phenotype02:27

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Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
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