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Updated: Sep 9, 2025

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

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Published on: March 11, 2020

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O-GlcNAcylation:脳の健康と神経変異を結びつける分子スイッチ

Nan Shao1, Xiaoyan Zhang2, Yunzhi Ge1

  • 1College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, Anhui Province, China.

Neural regeneration research
|September 4, 2025
PubMed
まとめ

O-リンクされたN-アセチルグルコサミン (O-GlcNAc) 改変は,タンパク質と細胞シグナル伝達を調節する脳の健康に不可欠です. O-GlcNAcの不均衡は神経変性疾患に寄与しますが,この経路をターゲットにすることは治療の可能性を秘めています.

キーワード:
アルツハイマー病ハンティントン病O-GLNAケースO結合のN-アセチルグルコサミンO結合のN-アセチルグルコサミントランスファーゼパーキンソン病アミオトロフィック・ラテラル・スクレロスヘクソサミンの生物合成経路神経再生神経変性神経機能

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