1型糖尿病の成人における高腰対身長比が心血管疾患のリスクを増加させる:全国的なコホート研究
Kyeong-Jin Kim1, Seohyun Kim1, Rosa Oh1
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Diabetes & metabolism journal
|September 4, 2025
まとめ
1型糖尿病 (T1DM) の患者では,高腰対身長比 (WHtR) によって示される中心的な肥満が,心血管疾患 (CVD) のリスクを有意に増加させる. WHtRによる早期発見は,この集団におけるCVDのリスクを管理するのに役立ちます.
科学分野:
- 心臓病科
- 内分泌学
- 公衆衛生
背景:
- 中枢の肥満は,心血管疾患 (CVD) と死亡率の既知の危険因子です.
- 腰と身長の比率 (WHtR) は中心的な肥満の実用的でアクセス可能なマーカーです.
- 1型糖尿病 (T1DM) の患者におけるWHtRと総合的な心血管疾患との関連については,さらなる調査が必要である.
研究 の 目的:
- 1型糖尿病 (T1DM) の成人における腰と身長比 (WHtR) と心血管 (CV) のアウトカムとの関連を調査する.
- T1DM集団におけるCVイベントの予測マーカーとして WHtRが機能するかどうかを判断する.
主な方法:
- 全国のT1DM患者 (16,928人) のコホート (2006年~2020年) を分析した.
- 参加者は3つのWHtRグループに分けられ,<0. 5,0. 5から<0. 6,および≥0. 6に分けられた.
- 主なアウトカムには,複合的な心筋梗塞 (心不全,心筋梗塞,不全性脳卒中,CVD関連死亡) が含まれており,個々の成分に対する二次分析が行われました.
主要な成果:
- WHtRの上昇と複合性心血管疾患のリスクの上昇との間に有意な関連性が見られた.
- WHtR < 0.5 と比較すると,WHtR ≥ 0. 6 は 1. 62 倍のリスクを示した (aHR 1. 62; 95% CI,1. 38- 1. 90; P < 0. 001).
- WHtRの上昇は,心不全,心筋梗塞,不全性脳卒中,およびCVD関連死亡のリスクの増加と関連していました.
結論:
- 1型糖尿病の成人の心血管疾患の有意な独立予測因子である.
- WHtRは,心血管合併症のリスクが高いT1DM患者の特定のための貴重なスクリーニングツールとして利用できます.
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