[軽度から中度までの一般的な不安障害の治療におけるSini Powderの改変:単一センター,ランダム化,ダブルブラインド,用量制御試験]
Jia-Xin Xu1, Hong-Jun Yang2, Hong-Wei Wu2
1Graduate School, Beijing University of Chinese Medicine Beijing 100029, China Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
まとめ
従来の投与量で修正されたSini Powderは,炎症に変容する肝臓うつ病の患者に一般的不安障害 (GAD) を効果的に治療します. この治療は,低用量治療と比較して優れた有効性と安全性を示しています.
科学分野:
- 統合医療
- 精神科
- 中国伝統医学 (TCM)
背景:
- 一般的な不安障害 (GAD) は,一般的な精神疾患です.
- GADに関連した特定のTCMパターンである.
- 改造されたシニ粉は,臨床で使用されるTCM製剤です.
研究 の 目的:
- 低用量製剤と比較して,従来の用量で改定されたSini Powderの有効性と安全性を評価する.
- 軽度から中等度のGADと特異的なTCM症候群の患者の治療結果を評価する.
- GADの治療におけるシニ粉末の最適用量を決定する.
主な方法:
- 単一センター,ランダム化,ダブルブラインド,用量制御試験が行われました.
- GADと炎症に変容する肝臓の低下を患った80人の患者が登録されました.
- 参加者はランダムに選択され,通常用量または低用量 (50%の有効成分) のシニ粉末の粒子を投与された.
主要な成果:
- 従来の用量群は,低用量群 (26. 6%) よりも著しく高い総応答率を示した.
- ハミルトン・アンキシー・スケール (HAMA) のスコアは,従来の用量群で8週間後により大きく低下した.
- HAMA体的不安症,TCM症候群のスコア,ピッツバーグ睡眠品質指数 (PSQI),および臨床総合印象 (CGI) のスコアを含む二次的アウトカムでは,従来の用量グループに著しく有利であった.
結論:
- 従来の投与量で修正されたSini Powderは,肝炎に変容する軽度から中等度のGADの治療に優れた有効性を示しています.
- 治療は好ましい安全性プロファイルを示し,副作用の発生率は低い.
- この患者群では,従来の投与量により改定されたSini Powderは低用量治療よりも推奨されます.
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