関連する実験動画

Updated: Sep 9, 2025

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
05:55

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System

Published on: December 21, 2019

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高度に安定したCas9は,HSC70媒介による分解を阻害することによって,HBVゲノム破壊を促進する

Zhongqing Li1,2, Yarong Song1,2, Hongxin Huang1,3

  • 1Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.

Emerging microbes & infections
|September 4, 2025
PubMed
まとめ

この研究は,サポーター媒介による自己消化によって,Cas9タンパク質がヒト細胞でどのように分解されるかを明らかにしています. 新しい高度に安定したCas9 (HSCas9) 変異体は,CRISPR/Cas9を強化して,B型肝炎ウイルス感染を効果的に排除します.

キーワード:
高度安定したCas9シェーパロン媒介による自動食死熱ショック関連タンパク質 70B型肝炎ウイルス

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