多民族の東南アジア初等保健医療集団における慢性腎臓疾患の初期段階における疾患進行に影響を与える要因

Hui Qi Koh¹, Xueling Sim², Sky Wei Chee Koh¹

¹National University Polyclinics, National University Health System, Singapore, Singapore.

Frontiers in medicine

|September 4, 2025

まとめ

慢性腎臓病 (CKD) の進行要因を早期に特定することは極めて重要です. マレー族,アルブミヌリア,糖尿病,高血圧,喫煙はCKDの進行リスクを増加させ,年齢と高 eGFRは減少させる.

科学分野:

腎臓科
主要な医療研究
流行病学について

背景:

慢性腎臓病 (CKD) の進行を遅らせるために有効なリスクファクター制御と薬剤の最適化が重要です.
初期段階のCKDの進行に影響を与える要因に関する研究は限られているが,特に初等医療環境ではそうである.

研究の目的:

2型糖尿病または高血圧の患者における初期段階のCKD (G1- G2) の進行に関連する要因を,初等医療の文脈で特定する.

主な方法:

初期のCKDと2型糖尿病または高血圧の19274人の患者のデータを遡及的に分析した (2017-2023年).
推定球球膜濾過率 (eGFR) の25%の低下またはCKDの悪化段階として定義される.
関連因子を特定するために使用される多変数ロジスティック回帰.

主要な成果:

CKDの進行は10. 3%の患者で観察されました.
進行リスクを増加させる要因: マレー民族,A2/A3 アルブミヌリア,糖尿病,高血圧,高血圧,喫煙,最大ACE阻害剤/ARB投与量,CKDカウンセリング.
発症リスクを低下させる要因: 年齢増加,高発血GFR,高発血血圧,高発血BMI

結論:

多民族のアジア人集団で確認された,早期のCKD進行に関連した主要な要因.
患者カウンセリングとSGLT2阻害剤の使用に関するさらなる研究が必要である.
洗練されたリスク分層は,高リスクのCKD患者のための標的型介入を可能にします.

キーワード:

CKDの進行慢性腎臓疾患患者教育プライマリケアリスク要因

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