関連する実験動画

Updated: Sep 9, 2025

Detection and Isolation of Apoptotic Bodies to High Purity
12:17

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

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NINJ1はアポプトティック細胞由来の大型細胞外小胞にオリゴメリー化し,小胞の安定性と細胞中の分泌量を調節する

Bo Shi1, Caolingzhi Tang2, Stephanie F Rutter1

  • 1Department of Biochemistry and Chemistry, Research Centre for Extracellular Vesicles, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.

Frontiers in immunology
|September 4, 2025
PubMed
まとめ

ニンジュリン-1 (NINJ1) タンパク質のオリゴメリゼーションは,アポプトティック体の膜破裂を調節し,炎症信号とウイルス粒子の放出を制御します. これはNINJ1を明確にします.

キーワード:
NINJ1 についてアポトーシスアポプトティック体細胞外小胞 (EVs)炎症ノロウイルスプラズマ膜の破裂

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The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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The Intrinsic Apoptotic Pathway01:31

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Apoptosis01:30

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