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Updated: Sep 9, 2025

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SB16と参照デノスマブの生物類似性を確認する集団の薬理動力学/薬理動力学分析

Seungchan Choi1,2, Suemin Park1, Jinah Jung3

  • 1Department of Clinical Pharmacology and Therapeutics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Frontiers in pharmacology
|September 4, 2025
PubMed
まとめ

この研究では,denosumab (DEN) と比較して,SB16の薬理動力学 (PK) と薬理動力学 (PD) を評価した. 結果はSB16がDENに似ていることを示し,骨粗鬆症の治療におけるその使用を裏付けている.

キーワード:
PK/PDモデリングとシミュレーションバイオシミラーデノスマブモノリックス骨粗鬆症ターゲットメディエイトド・ドラッグ・ディポジション

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