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Updated: Sep 9, 2025

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

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抗がん剤のメカニズム的支架としての新しいグアニジン誘導体:合成,特徴付け,DNA結合,計算研究

Hina Zaman1, Aamer Saeed1, Uzma Azam1

  • 1Department of Chemistry, Quaid-I-Azam University Islamabad 45320 Pakistan asaeed@qau.edu.pk +92-51-9064-2241 +92-51-9064-2128.

RSC advances
|September 4, 2025
PubMed
まとめ

新しいグアニジンの誘導体は,DNAの小さな溝に選択的に結合することで,抗がん剤として有望であることが示されています. 化合物7iは重要なDNA結合親和性を示し,将来のがん薬の開発の可能性を裏付けました.

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