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イタリアの異なる宿主からのStreptococcus canisのゲノム解析:多様性,抗菌剤耐性,および毒性プロファイル
Lucilla Cucco1, Elisa Albini1, Francesca Blasi1
1Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Perugia, Italy.
Frontiers in veterinary science
|September 4, 2025
まとめ
複数の宿主を持つ病原体であるStreptococcus canisは,イタリアでベータラクトームに対する感受性を示しています. ST9は 主要なクローンであり,多様性があるものの,病原体は新しいニッチに適応していないため,ヒトの偶然感染が確認されています.
科学分野:
- 獣医学微生物学
- 抗菌剤に対する耐性
- ゲノミクス
背景:
- Streptococcus canisは,家畜に見られる多宿主病原体です.
- ヒトの感染は時々報告され,しばしば重症である.
- 遺伝的多様性と耐性を理解することは 極めて重要です
研究 の 目的:
- イタリアにおけるS. canisの遺伝的多様性,抗菌剤耐性 (AMR) と病原性を調査する.
- 臨床症例から分離されたS. canisの特徴 (2004年-2021年)
- 流行する配列型 (ST) と抗菌剤耐性遺伝子を特定する.
主な方法:
- 55個のS. canisの全ゲノム配列解析 (WGS) について
- 抗菌感受性テスト
- 公的S. canisゲノムデータとの比較ゲノミクス
主要な成果:
- リンコサミド,テトラサイクリン,マクロリドに対する耐性が一般的であった.
- 6つの単離 (2020-2021) は多剤耐性 (MDR) であった.
- ST9は最も一般的な配列型で,ssp-5の毒性遺伝子は43の単離体で検出されました.
- 宿主,地域,年によってではなく,SCMタンパク質遺伝子とSTによってクラスタ化されたイタリアの単離物.
結論:
- イタリアではベータラクトーム抗生物質がS. canis感染に対して有効である.
- ST9はイタリアで支配的なクローンです.
- S. canisは新しい生態系に適応できず,人への感染の偶然性を支持しています.
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