スイスの酪農場で発生したColchicum autumnaleの毒害: 牛乳の安全性に関する概要
Karen Barmettler1, Adrian Fäh2, Hanspeter Naegeli3
1Institute for Food Safety and Hygiene, Vetsuisse Faculty, University of Zurich.
Italian journal of food safety
|September 4, 2025
まとめ
乳牛の秋のクロカスによるコルキシン中毒は,乳の供給停止を引き起こした. ミルクは被曝から2週間後に陽性となり 5週間後に陰性となり,出産が再開されました.
科学分野:
- 獣医学毒理学
- 食品の安全性
- 乳製品科学
背景:
- コルチカム・オータムナレ (秋のクロカス) の摂取は,家畜,特に乳牛に重大な危険をもたらします.
- コルキシン中毒は 深刻な臨床症状と 乳牛飼育の経済的損失をもたらす可能性があります
- コルキシンによる牛乳の汚染は,その毒性と規制上の影響により懸念される.
研究 の 目的:
- ブラウン・スイス牛の コルキシン中毒の報告 秋のクロカスの摂取による
- 牛乳サンプルにおけるコルキシンの持続性を調査する.
- 乳牛の群れにおける有毒植物被曝のモニタリングの重要性を強調する.
主な方法:
- 感染した牛の臨床症例観察と獣医の介入
- 乳中のコルキシン検出のためのタンデム質量スペクトロメトリー (LC-MS/MS) と結合した液体クロマトグラフィー
- 食品中のコルキシンに関する毒理学的データと規制枠組みの検討
主要な成果:
- 牛は無関心,低体温,秋のクロカスを食べた後の乳量低下などの臨床症状を示した.
- 牛乳のサンプルで コルキシンが検出されたのは 毒性の発生から2週間後でした
- 暴露後5週間で大量の牛乳の検査結果が陰性となり,牛乳の供給が再開されました.
結論:
- 乳牛のコルキシン暴露は,牛乳の汚染を防ぐために慎重に管理する必要があります.
- LC-MS/MSのような分析方法は,牛乳中のコルキシンを検出し,食品の安全性を確保するために不可欠です.
- 飼料から食品への化学薬品の危険性の管理には,検出限界値と予備期間を定めることが不可欠です.
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