関連する実験動画

Updated: Sep 9, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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低メチル化剤は,骨髄性悪性腫瘍の新規挿入を誘導することなく,L1レトロエレメント発現を増加させる

Šárka Pavlová1,2,3, Hana Svozilová1,2,3, Marcela Krzyžánková1

  • 1Department of Internal Medicine - Hematology and Oncology, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic.

Molecular oncology
|September 4, 2025
PubMed
まとめ

低メチル化剤は白血病細胞におけるレトロエレメントタンパク質の発現を増加させるが,長期にわたる曝露でも,新しい体内レトロトランスポーゼーション現象を引き起こさない. これは,これらの薬剤が,レトロエレメント活動によって疾患の進行を誘導しないことを示唆している.

キーワード:
5′-アザチチジンL1 についてライン-1ORF1pORF2pハイポメチル化剤骨髄不形成症候群リトロトランスポジション適用可能な要素

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