V/D/J遺伝子の偏った使用とIgGレパートリーにおけるクローン多様性は,全身性自己免疫疾患における疾患活動と臨床的特徴と相関する

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Updated: Sep 9, 2025

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
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VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

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Qian Wang1, Delong Feng1, Yang Song1

  • 1Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.

Immunological investigations
|September 4, 2025
PubMed
まとめ

系統的自己免疫疾患 (SAID) のB細胞受容体 (BCR) IgGレパートリーの特徴は,明確なパターンを示しています. これらの免疫障害は,疾患の進行と標的治療のバイオマーカーとして機能する.

キーワード:
IgGのレパートリーシステム性自己免疫疾患臨床的特徴リウマチ性関節炎全身性赤血性狼

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