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Updated: Nov 6, 2025

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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ベネトクラックス/アザシチジンに対するUBTF-TDによるブラスト過剰の小児骨髄膜症候群の感受性

Pietro Merli1,2, Riccardo Masetti3,4, Martina Pigazzi5,6

  • 1Department of Pediatric Hematology/Oncology, Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

American journal of hematology
|September 4, 2025
PubMed
まとめ

ベネトクラックスとアザシチジン (ven/ aza) による治療は,UBTF- TD Myelodysplastic Syndromes with Excess Blasts (MDS- EB) の小児患者で有望な結果を示した. すべての患者は寛解を達成し,幹細胞移植に成功しました.

キーワード:
骨髄不形成症候群neoplasia- 薬剤療法について小児血液学/腫瘍学

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Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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