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Updated: Sep 9, 2025

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

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SARS-CoV-2のRGDモチーフは,TGF-βシグナル伝達を誘導し,インターフェロンを低下させる

Nicholas P Gracie1, Anupriya Aggarwal2, Rachel Luo1

  • 1School of Life and Environmental Sciences, The University of Sydney, Camperdown, New South Wales, Australia.

Journal of virology
|September 4, 2025
PubMed
まとめ

SARS-CoV-2のスパイクタンパク質

キーワード:
コロナウイルスIFN-βPAI-1 についてRGD (アルグライアスプ)SARS-CoV-2についてTGF-βコロナウイルスインテグリン

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TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

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Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
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G protein-coupled receptor (GPCR) signaling plays a crucial role in cell functioning. GPCR desensitization is an equally essential process. It allows cells to respond to changing environments and regain sensitivity to new stimuli while preventing unnecessary stimulation when no longer needed. Prolonged exposure to stimuli leads to GPCR desensitization. It involves blocking the receptors from binding and activating additional G proteins. This inhibits activation of downstream effectors, thereby...
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