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Updated: Sep 9, 2025

Identification of Kinase-substrate Pairs Using High Throughput Screening
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Rab-phosphorylating kinasesの選択性プロファイルと基板認識について

Deep Chatterjee1,2, Verena Dederer1,2, Landon Vu Nguyen3

  • 1Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt , 60438, Germany.

The Biochemical journal
|September 4, 2025
PubMed
まとめ

この研究は,Rab GTPaseのリン酸化がパーキンソン病のリスクにどのように影響するかを明らかにしています. 研究者は新しいキナーゼ-ラブ相互作用を特定し,これらの重要な改変をよりよく研究するためにラブ変種を設計しました.

キーワード:
GTPフェーズ酵素活性酵素学キナーゼレウシンに富んだリピートキナーゼシナプスベシクル

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