静脈血栓塞栓症前の身体活動と集団ベースの発症コホートにおける再発リスク
Anna C Frauenheim1, Kerri L Wiggins2, Rozenn N Lemaitre2
1Department of Epidemiology, University of Washington, 1410 NE Campus Pkwy, Seattle, WA, 98195, USA. afrauen@uw.edu.
Journal of thrombosis and thrombolysis
|September 4, 2025
まとめ
定期的な中等から激しい身体活動 (MVPA) は,再発性静脈血栓塞栓症 (VTE) のリスクを低下させるようには見えませんでした. この研究では,前回のVTEイベントを経験した成人のMVPA濃度とVTE再発との間には関連性が見出されなかった.
科学分野:
- 心血管の健康
- 運動 生理学
- トロンボシス 研究
背景:
- 身体活動と再発性静脈血栓塞栓症 (VTE) の関係については,さらなる調査が必要である.
- この関連性を理解することで,公衆衛生のガイドラインと患者への勧告を 導き出せるでしょう.
研究 の 目的:
- 適度から激しい運動 (MVPA) と再発性VTEのリスクとの関連を調べる.
- 大人のVTE再発に MVPAのレベルが影響するかどうかを判断する.
主な方法:
- 事件性VTEを患った1381人の成人を対象にコホート研究が行われました.
- 中等から激しい身体活動 (MVPA) は自己報告され,毎週MET時間で定量化されました.
- VTEの再発リスクを分析するためにコックス比例リスクモデルを使用した.
主要な成果:
- MVPAとVTEの再発の有意な関連は見つかりませんでした (HRadj=1. 24).
- MVPA患者では,継続的なMET時間/週も,四分位数もVTE再発との関連性を示さなかった.
- 中程度の強度のPAの二次分析も再発との関連性がないことを明らかにした.
結論:
- VTE発生前に自己報告されたMVPAは,VTE再発のリスクの減少と関連しませんでした.
- 現在の研究結果から 身体活動のレベルは VTE 再発の有意な要因ではないと示唆されています
- VTE再発の他の潜在的変更可能な危険因子を調査するには,さらなる研究が必要です.
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