吸入された大麻,喘息,慢性閉塞性肺疾患:n = 379,049の集団ベースの横断研究
Alison S Rustagi1,2, Abra M Jeffers3,4,5, F Julian Graham6,7
1Center for Data to Discovery and Delivery Innovation (3DI), San Francisco VA Health Care System, San Francisco, CA, USA. alison.rustagi@va.gov.
Journal of general internal medicine
|September 4, 2025
まとめ
吸入された大麻の使用は,たばこの使用を除外しても,喘息や慢性閉塞性肺疾患の発生率の増加と関連しています. これは大麻がこれらの呼吸器疾患の 修正可能な危険因子である可能性を示唆しています
科学分野:
- 肺医学
- 流行病学
- 公衆衛生
背景:
- 大麻の使用は増加しており,呼吸器の健康への影響を懸念しています.
- これまでの大麻と肺疾患に関する研究は,少量のサンプルとタバコ使用に対する不十分な管理によって制限されています.
- 吸入された大麻が呼吸器疾患に及ぼす独立した影響を理解することは,公衆衛生の指針にとって極めて重要です.
研究 の 目的:
- 吸入された大麻の使用と喘息および慢性閉塞性肺疾患 (COPD) の流行との関連を調査する.
- これらの関連が,同時または過去のタバコ使用とは無関係に存続するかどうかを判断する.
- 生涯にわたってタバコに接触していないサブグループを含む,全国的に代表的な大きなサンプルで関係を調べる.
主な方法:
- 2016-2020年の行動リスク因子監視システム (BRFSS) の横断分析.
- 喘息やCOPDの診断を受けた18歳から74歳の成人を含む.
- マルチ変数ロジスティック回帰モデルは,過去30日間の大麻使用に関連した病気の確率を評価するために使用され,社会人口統計とタバコ使用歴を調整しました.
主要な成果:
- 毎日吸入した大麻の使用は,全体的に (aOR1.44) 喘息の確率と,生涯にわたってたばこを吸っていない人では (aOR1.51) 確率と有意に関連していた.
- 毎日吸入した大麻の使用は,全体的にCOPDの確率の増加と関連していた (aOR1.27).
- 日常の大麻使用とCOPDとの関連は,生涯喫煙しないサブグループでは統計的に有意ではなかった (aOR1. 54).
結論:
- 吸入された大麻の使用は,タバコの喫煙とは無関係に,喘息とCOPDの両方に有意な関連性を示しています.
- 日常の大麻使用と喘息との関連は,たばこを吸ったことのない人でも顕著である.
- 大麻は,喘息やCOPDの発症や悪化に寄与する変化可能な危険因子である可能性があります.
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