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Updated: Sep 9, 2025

Label-Free Non-Linear Optics for the Study of Tubulin-Dependent Defects in Central Myelin
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TDP-43の調節障害は,ミエリン化欠陥に関連したコレステロール代謝を損なう

Irene García-Toledo1, Juan M Godoy-Corchuelo1, Luis C Fernández-Beltrán1,2

  • 1Neurological Disorders Group, Hospital Clínico San Carlos, IdISSC, Madrid, Spain.

Acta neuropathologica
|September 4, 2025
PubMed
まとめ

TDP-43の機能障害は,脳コレステロールのホメオスタシスを破壊し,ALSやFTDのような神経変性疾患では,脂質代謝と潜在的にミエリン整合性に影響を及ぼします. この研究は,マウスモデルとFTLD-TDP患者における脂質経路の変化とコレステロール合成の障害を明らかにした.

キーワード:
コレステロール代謝脂質の滴リピドミクスミエリンTDP-43 タンパク質病変トランスクリプトミクス

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