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Updated: Sep 9, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

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マルチオミクスは,クローン病における腸内記憶CD4+T細胞の転写プログラムを発見した

Mitsuru Arase1,2, Mari Murakami1,2, Takako Kihara3

  • 1Department of Microbiology and Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.

The Journal of experimental medicine
|September 4, 2025
PubMed
まとめ

クローン病における組織内定記憶T細胞 (TRM) は,RUNX2とBHLHE40によって調節される. これらの要因は疾患特有のT細胞特性を駆動し,その調節は病原性フェノタイプに影響を与え,治療標的を提供します.

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