骨粗鬆症の治療歴と第2回ゾレドロン酸投与の関係
Natalia Konstantelos1, Sandra Kim2,3, Angela M Cheung4,5
1Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada. natalia.konstantelos@gmail.com.
まとめ
ゾレドロン酸を投与された大部分の骨粗鬆症患者は,以前の治療を受けていた. 前回の口服ビスホスフォネート投与を受けた患者は,第2回ゾレドロン酸注入を受ける可能性が高く,患者の決定を理解する必要性を強調した.
科学分野:
- 骨粗鬆症の薬剤療法
- ビスホスフォネート処理
- 医療管理データの分析
背景:
- ゾレドロニン酸はカナダのオンタリオ州で重要な二次骨粗鬆症の治療法である.
- ゾレドロニン酸の臨床試験では,主に未経験の患者を用いた.
- ゾレドロン酸を投与する実際の患者集団は,以前から骨粗鬆症の薬を服用していたことが多い.
研究 の 目的:
- オンタリオ州でゾレドロニン酸を投与する患者の特徴
- 以前の骨粗鬆症の薬剤療法がゾレドロン酸の投与頻度に影響するかどうかを判断する.
- 第2回ゾレドロン酸注入の受け取りに影響する要因を特定する.
主な方法:
- オンタリオ州の医療管理データ (2006年-2021年) の分析
- 5年間の薬物使用歴に基づいて患者の分類 (無薬,デノスマブ,口服用ビスホスフォネート,その他).
- コックスの比例的危険性モデルで,第二回接種をグループごとに比較する.
主要な成果:
- 患者3308人がゾレドロン酸投与を開始し,31%が第2回輸血を受けた.
- 49%は以前から口服ビスホスフォネートを使用しており,37%は治療歴がありません.
- 前回の口服ビスホスフォネート投与は,第2回投与の確率を1.5倍に増加させた (HR: 1. 50 [1. 31 - 1.71]).
結論:
- ゾレドロン酸の受容者の大半は,骨粗鬆症の治療経験がある.
- 以前,口服用ビスホスフォネートで治療を受けた患者は,第2回ゾレドロン酸の投与率が高かった.
- ゾレドロン酸に関する患者の信念と治療決定に関するさらなる研究が必要である.
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