アルコール使用障害や急性中毒の精神病患者の薬剤療法:観察薬剤監視プログラム状況と2000年から2016年の変化
Beatrice Haack1, Johanna Engel2, Philipp Pauwels2
1University Department of Psychiatry and Psychotherapy, Brandenburg Medical School, Immanuel Klinik Rüdersdorf, 15562, Rüdersdorf, Germany. beatrice.haack@mhb-fontane.de.
Journal of neural transmission (Vienna, Austria : 1996)
|September 4, 2025
まとめ
この研究は,アルコール使用障害 (AUD) の入院患者10,332人の精神薬の使用を分析した. 抗うつ薬と抗精神病薬が増加し,証拠に基づかない鎮静剤が頻繁に使用され,併発症の管理の必要性が強調されました.
科学分野:
- 精神医学と薬理学
- 薬物の安全性に関する研究
背景:
- アルコール使用障害 (AUD) は,しばしば入院治療を必要とする一般的な精神障害です.
- AUDの離脱と解毒の薬理学的管理は,通常,鎮静剤,抗剤,および症状誘発療法を含む.
研究 の 目的:
- AUDと急性中毒の入院治療における精神薬の使用を調査する.
- 薬物使用の傾向を分析し,患者の特徴に基づく変化を特定する.
主な方法:
- 2000年から2016年の間に治療を受けたICD-10コードF10の患者10,332人のデータを分析した.
- 精神医学における薬物安全性プログラム (AMSP) のデータです.
- 抗うつ薬,抗精神病薬,抗発作薬,鎮静剤を含む薬剤のクラスを調べる
主要な成果:
- 抗うつ薬 (31.2%) と抗精神病薬 (29. 7%) が最も一般的であり,それに抗薬 (26. 4%) と鎮静剤 (24. 3%,主にベンゾジアゼピン) が続いた.
- カーバマゼピン,ディアゼパム,ミルタザピン,オクサゼパムは頻繁に処方されました.
- 抗うつ薬と抗精神病薬の使用は増加し 鎮静剤の使用は倍増し クロメチアゾールの使用は減少しました
- 非ベンゾジアゼピン鎮静剤 (トラゾドン,ミルタザピン,クエチアピン) の高い利用率は,限られた証拠にもかかわらず観察された.
結論:
- AUDの治療パターンは 性別や併発症,特にうつ病によって異なります.
- 抗うつ薬と抗精神病薬の使用が増えることは 治療戦略の進化を反映しています
- ベンゾジアゼピン以外の鎮静剤の頻繁な使用は,十分な証拠がないため,さらなる調査が必要である.
- AUDの治療における併発症の管理に より大きな注意を払うことは極めて重要です.
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