非アルコール性脂肪肝疾患における肝細胞からの外体LncRNA MALAT1 阻害性睡眠時無呼吸症候群を悪化させる miR-579-3p/Keap1/Nrf2経路を調節する

関連する実験動画

Updated: Sep 9, 2025

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

25.5K

Lulu Gan1, Anni Dai1, Yan He1

  • 1Hypertension Center, Yan'an Hospital Affiliated to Kunming Medical University, Kunming Technical Diagnosis and Treatment Center for Refractory Hypertension, No.245 Renmin East Road, Kunming, 650000, Yunnan, China.

Molecular biotechnology
|September 4, 2025
PubMed
まとめ

非アルコール性脂肪肝 (NAFLD) のエクソソームには lncRNA MALAT1 が含まれており,脳細胞に損傷を与えることで 阻害性睡眠呼吸停止症候群 (OSAS) を悪化させる. これはMALAT1/miR-579-3p/Keap1-Nrf2経路を通じて発生し,肝疾患と睡眠時無呼吸症の神経学的影響の関連性を強調しています.

キーワード:
慢性的な中断性低酸素海馬の神経細胞キープ1/Nrf2LncRNA MALTA1 について非アルコール性脂肪肝阻害性睡眠無呼吸症候群

さらに関連する動画

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.3K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.0K

関連する概念動画

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.6K
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
2.4K