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Updated: Sep 9, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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2型糖尿病を標的とする新しいSHP-2阻害剤の計算による洞察と活性評価

Rong Liu1,2, Liang Zou1,2, Maoqi Wang1

  • 1School of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.

Molecular diversity
|September 4, 2025
PubMed
まとめ

研究者は,何百万もの化合物をスクリーニングすることによって,2型糖尿病 (T2DM) の新しいSHP-2阻害剤を特定しました. これらの阻害剤は,SHP-2タンパク質の活性を標的として,インスリン抵抗性の治療の可能性を示しています.

キーワード:
分子ドッキング分子ダイナミクスシミュレーションSHP-2 阻害剤2 型糖尿病

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