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Updated: Dec 25, 2025

Electroporation-Mediated Delivery of Cas9 Ribonucleoproteins and mRNA into Freshly Isolated Primary Mouse Hepatocytes
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"治療法"ではなく"ショック":エレクトロポレーションにより,肝細胞遺伝子編集療法における疾患特有の制約が明らかになった

Callie Clark1, Menam Pokhrel1, Benjamin Arthur1

  • 1Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.

Biology
|September 4, 2025
PubMed
まとめ

シトクロームP450酸化還元酵素 (Cypor) を標的にするCRISPR- Cas9遺伝子編集は,電解とアセトアミノフェン選択で,家族性高コレステロール症では有効ではありません. サイポールの欠乏はコレステロール代謝を阻害し,マウスの治療効果を阻害する.

キーワード:
CRISPR-Cas9について動脈硬化症電解孔家族性高コレステロール症遺伝子編集肝臓細胞移植肝臓の研究

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