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Updated: Sep 8, 2025

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
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HER2- VEGFA BsAbによって誘発されたVEGFAとHER2- 過剰発現するがん細胞の共ファゴシトーシスは,抗腫瘍反応を改善する

Yang Lu1, Songbo Qiu1, Zhen Fan1

  • 1Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, United States of America.

JCI insight
|September 4, 2025
PubMed
まとめ

HER2とVEGFAを標的にする二固有の抗体は,がん細胞と腫瘍を誘発する成長因子をマクロファージに吸収させることで,抗腫瘍活動を強化する. この新しいアプローチは,臨床前モデルの生存率を向上させ,転移を減少させます.

キーワード:
臨床研究免疫学腫瘍学治療薬

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