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Updated: Sep 8, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

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GPRC5Bは,MafA発現を制御することによって,肥満における成熟したβ細胞状態を維持する

Tianpeng Wang1, Remy Bonnavion1, Janett Piesker2

  • 1Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

JCI insight
|September 4, 2025
PubMed
まとめ

孤児受容体GPRC5Bは,肥満中の臓β細胞機能を維持するために不可欠です. その喪失は,cAMP/ CREB経路を通じてベータ細胞の成熟とMafA発現に影響を与え,インスリン分泌とグルコース耐性を損なう.

キーワード:
ベータ細胞内分泌学Gタンパク質結合受容体メタボリズム肥満

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